Rosario to Vampire tells the story of Tsukune, an ordinary high schooler who accidentally enrolls in Youkai Academy, a school for monsters disguised as humans.
The academy's strict rule is that any human discovered on campus must be eliminated. Tsukune, oblivious to the danger, befriends Moka, a beautiful girl who turns out to be a vampire.
Driven by his attraction to Moka, Tsukune decides to remain at the monster school, navigating the perilous environment and dealing with a host of other attractive but dangerous creatures.
The anime focuses on Tsukune's experiences, romantic entanglements, and comedic misadventures as he tries to survive in a school filled with supernatural beings while keeping his human identity a secret.