Oniisama e... follows Nanako as she begins her life at the exclusive Seiran Academy. Expecting a positive experience, she instead finds herself caught in complicated social dynamics and unexpected challenges.
Chosen for a coveted spot in the school's Sorority, Nanako quickly becomes the target of jealousy and resentment, particularly from a classmate named Aya.
To navigate the difficulties of her new environment, Nanako finds solace in writing letters to her former teacher, whom she considers a brother figure. She also relies on the support of a small circle of close friends.
The story explores themes of bullying, social pressure, and the trials faced by a young girl as she attempts to adjust to a demanding and unforgiving school setting.