Ansatsu Kyoushitsu revolves around Class 3-E, a group of underachieving students at Kunugigaoka Middle School. They're given a seemingly impossible task: assassinate their new teacher, Koro-sensei, an octopus-like being who destroyed part of the moon and threatens to destroy Earth within a year.
Despite his terrifying abilities, including superhuman speed and resilience, Koro-sensei is determined to be a fantastic teacher. He aims to improve their academics and teach them assassination skills, believing in their potential to return to the main campus.
The series follows Nagisa Shiota and his classmates as they struggle to find Koro-sensei's weaknesses and improve their skills, balancing their studies with the high-stakes mission of saving the world.