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Ochame na Futago: Claire Gakuin Monogatari tells the story of twin sisters, Patricia and Isabel O'Sullivan, as they begin their lives at St. Claire's, a girls' college.
The anime focuses on their experiences there, introducing us to their new friends: Alison, Wella, Catherine, and Doris.
Together, these girls enjoy a harmonious and playful life at the college, forming strong bonds and participating in various activities.
However, their peaceful existence is disrupted by the arrival of Winfred, a difficult and unfriendly girl who seems determined to cause trouble for the twins and their friends.