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The story of IS: Infinite Stratos revolves around Ichika Orimura, a seemingly ordinary teenage boy who unexpectedly discovers he's the only male capable of piloting the incredibly powerful Infinite Stratos (IS) exoskeletons.
Due to the IS's immense potential for destruction, its use is strictly regulated by an international treaty.
Ichika's unique ability forces him to enroll in the prestigious Infinite Stratos Academy, a predominantly female boarding school dedicated to training future IS pilots.
Surrounded by talented and competitive girls, including childhood friends and new acquaintances, Ichika must navigate the challenges of academy life while learning to master the IS.
Under the watchful eye of his older sister and homeroom teacher, Chifuyu Orimura, Ichika and his classmates will face various threats that endanger the academy and their safety.
The series follows their journey as they strive to protect themselves and the school from these dangers, utilizing their skills and the power of the IS.